Anything from Blue Orange. These are really creative. We have
Yamslam kind of like poker + Yahtzee merged together
Spot It you need to find what is the same on the two cards - a lot harder than it sounds
Tell Tale you deal out 3 cards per person then take turns telling the story. Turn over your card to see where you need to take the story - this can be very funny!
We also play Yahtzee, card games (King's corners, Saskatchewan Rummy, Rummoli, 4-card Golf, 6-card Golf).
Ligretto (lots of fun with 4+ people).
And we just got Apples to Apples Junior - great for the kids once they can read. Also fun with 4+ people.
If you have a wordsmith, try
Pick Two - you arrange your letters to form words in a crossword type of way, and then yell pick 2 when you've used up all your letters (and everyone grabs 2 more letters). Very creative thinking here, not to mention spelling skills.