Which do you set Photoshop to? I don't quite get using one or the other (even after reading several Google responses), but I've been bothered that my colors on printed projects are not true to what I see on my screen. Browns take on a bluish tone. Black isn't pure black. etc. I just did a test. My cpu had been set to RGB. I switched it to CMYK, and there was no appreciable difference in the printed layouts. I also clicked to let the computer (adobe) control the colors. I am NOT a TECHIE, so this sort of thing is a total mystery to me. I'm using PSCC on an iMac with an Epson ET-2760 (tank) printer. TIA for any input.